INTEGRATED MULTIOMIC ANALYSIS REVEALS THE HIGH-FAT DIET INDUCED ACTIVATION OF THE MAPK SIGNALING AND INFLAMMATION ASSOCIATED METABOLIC CASCADES VIA HISTONE MODIFICATION IN ADIPOSE TISSUES

BackgroundThe number of diet induced obese population is increasing every year, and the incidence of type 2 diabetes is also on the rise.Histone methylation and acetylation have been shown to be associated with lipogenesis and obesity by manipulating gene expression via the formation motovox scooter parts of repression or activation domains on chro

Background: In order to protect public health during the outbreaks of infectious diseases including the pandemic COVID-19, provision of Water, Sanitation, and Hygiene (WASH) services is important.The challenges of inaccessible WASH services along with the pandemic COVID-19 in low-income countries can lead to a devastating problem.Method: A systemat

Characterized by positive symptoms (such as changes in behavior or thoughts, including delusions and hallucinations), negative symptoms (such as apathy, anhedonia, and social withdrawal), and cognitive impairments, schizophrenia is a chronic, severe, and disabling mental disorder with late adolescence or early adulthood onset.Antipsychotics are the

PAR-2 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases.In order to evaluate the therapeutic potential for PAR-2, we have here performed studies on PAR-2-mediated signal transduction and investigated the effects of PAR-2 gene deficiency in disease models.In addi